Tfh IL21 help
Gene co-expression module in CD4⁺ T cells
| Category | B cell help |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 15 genes have a known function matching the annotation |
Why this annotation
Clear Tfh/B cell help module: IL21 (defining Tfh effector cytokine), PDCD1 (PD-1, high on Tfh), MYB (Tfh differentiation TF), TNFSF8 (CD30L), HIF1A. Strong inflammation association and remission reversal. Sits beside M67 (Tfh) reinforcing the B cell help program.
Genes
APBB2, CDYL2, GDF7, HIF1A, IL21, KIAA1671, MFHAS1, MYB, PDCD1, PHEX, PHF6, PLXND1, PTPN13, SMPDL3A, TNFSF8
Most correlated modules
- NFAT activation · correlation 0.78
- T cell exhaustion · correlation 0.73
- Tfh CXCL13 program · correlation 0.71
- Integrin adhesion · correlation 0.65
- Tfh program · correlation 0.59
- CD200 immunoregulation · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.