LRBA — LPS responsive beige-like anchor protein
LRBA belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRBA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell exhaustion Exhaustion | CD247, CD38, CD59, FLT1, GAN, IKBKB, LAG3, PTMS +3 more | View in SCUBA |
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ARL15, BLNK, CERS6, EXT1, FHIT, FUT8, KANK1, LDLRAD4 +6 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, CHD8, DOCK2, EP400, ERBIN, GOLM2, IPO8 +17 more | |
| Innate lymphoid cells | Centrosome & Scaffolding Cytoskeleton & motility | AKAP9, APPL1, ARID4A, CCDC91, CPNE3, ETNK1, FAM204A, GOPC +14 more | View in SCUBA |
| Lymphatic endothelial | Polarized Vesicle Trafficking migration & adhesion | ELMO1, EXOC4, EXOC6B, IMMP2L, L3MBTL4, LRMDA, MYO9A, PARD3B +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more |
About the gene
| Synonyms | BGL, CDC4L, LAB300, LBA |
|---|---|
| Chromosome | 4: 150264435-151015727 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
Involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.