SYNGR2 — Synaptogyrin 2

SYNGR2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SYNGR2's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Regulatory T cell Immune regulation	ATP1B1, EBI3, FOXP3, GADD45A, GCNT1, GTF2H5, IL1R1, IL1R2 +6 more	View in SCUBA
CD8⁺ T cells	BATF-driven Activation T cell maturation	ARL6IP5, BATF, CD82, IL2RG, LAMTOR5, SCAMP2, SH2D2A, SQSTM1 +2 more	View in SCUBA
Endothelial	Endothelial Barrier Homeostasis migration & adhesion	AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2 +11 more	View in SCUBA
Hematopoietic progenitor cells	ER Protein Folding Housekeeping	ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2 +13 more
Innate lymphoid cells	Interferon-Stimulated Genes Inflammation	ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA +17 more	View in SCUBA
Macrophages	Lysosomal Hydrolase Program Lysosomal & pahgocytosis	AMDHD2, ARL6IP5, ARPIN, ARSA, CD81, CLDN7, CLEC2B, COMT +35 more	View in SCUBA

About the gene

Chromosome	17: 78168581-78173527
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted membrane proteins
Biological process	Host-virus interaction

Function

May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.