SCUBA

SH2D2A — SH2 domain containing 2A

SH2D2A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SH2D2A's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsProteasome translation
Housekeeping		ADRM1, CD2BP2, CDV3, CST7, EHBP1L1, EIF3J, ENO1, HSBP1 +5 moreView in SCUBA
CD8⁺ T cellsBATF-driven Activation
T cell maturation		ARL6IP5, BATF, CD82, IL2RG, LAMTOR5, SCAMP2, SQSTM1, SYNGR2 +2 moreView in SCUBA
Gamma-delta T cellsT Cell Exhaustion
Exhaustion		ACADVL, ACSS1, ADSS2, B4GALT3, CDK11A, CHP1, CNOT2, CNOT8 +20 more
Innate lymphoid cellscAMP-Glucocorticoid Suppression
Immune regulation		CD7, CERK, CNDP2, COA1, NAP1L4, NEK7, NR3C1, PDE3B +3 moreView in SCUBA
Mucosal-associated invariant T cellMAIT Cell Identity
T cell maturation		AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more
Natural Killer cellsNK Cell Exhaustion
Immune regulation		CEBPB, CEMIP2, DENND3, FMNL1, HAVCR2, IFNGR1, METRNL, PDE4D +3 moreView in SCUBA

About the gene

SynonymsF2771, TSAd
Chromosome1: 156806243-156816848
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Molecular functionDevelopmental protein
Biological processAngiogenesis, Differentiation

Function

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK- dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.