TNFRSF18 — TNF receptor superfamily member 18
TNFRSF18 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, CTLA4, DNPH1, GBP2, IL2RA, NAMPT, NDFIP2 +6 more | View in SCUBA |
| CD8⁺ T cells | BATF-driven Activation T cell maturation | ARL6IP5, BATF, CD82, IL2RG, LAMTOR5, SCAMP2, SH2D2A, SQSTM1 +2 more | View in SCUBA |
| Gamma-delta T cells | IRF4 T-cell Activation T cell maturation | APOA1, APOA4, CD59, FCER1G, FES, FUCA1, GEM, GRAMD2B +14 more | |
| Hematopoietic progenitor cells | Regulatory T-cell State Lymphcyte development | CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A +9 more | |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Natural Killer cells | NK Cytoskeletal Activation Cytoskeleton & motility | CAPG, CLNK, COTL1, EVL, GPR82, ITM2A, PEBP1, PGK1 +3 more | View in SCUBA |
About the gene
| Synonyms | AITR, CD357, GITR |
|---|---|
| Chromosome | 1: 1203508-1206592 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Apoptosis |
Function
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.