TCR Proximal Signaling
Gene co-expression module in CD8⁺ T cells
| Category | TCR Signaling |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes: ZNHIT1 (zinc finger HIT domain, involved in H2A.Z histone exchange/chromatin remodeling via SRCAP complex), PRDX5 (peroxiredoxin, antioxidant/stress), CSK (C-terminal Src kinase, negative regulator of Lck/TCR signaling), HCLS1 (hematopoietic cell-specific Lyn substrate 1, actin dynamics in lymphocytes/BCR-TCR signaling), MAP2K2 (MEK2, MAPK signaling), SRP14 (signal recognition particle), NOP10 (ribosome biogenesis/telomerase), MPG (DNA repair glycosylase), CHMP2A (ESCRT-III, membrane/endosome). The module is heterogeneous (moderate coherence, many weak members). The top hub ZNHIT1 and CSK/HCLS1/MAP2K2 suggest a mixed program touching chromatin regulation, TCR/Src kinase modulation, and lymphocyte-specific actin signaling. Closest coherent theme: T cell signaling regulation (CSK inhibits Lck, HCLS1 links BCR/TCR to actin). Given neighbor M30 (actin cytoskeleton) and M83 (MHC/antigen presentation), this may represent a TCR proximal signaling/regulatory module.
Genes
CHMP2A, CSK, HCLS1, MAP2K2, MPG, NOP10, PRDX5, SRP14, ZNHIT1
Most correlated modules
- ER Protein Quality Control · correlation 0.94
- ER-Golgi Trafficking · correlation 0.94
- Mitochondrial OxPhos · correlation 0.91
- Actin Cytoskeleton Dynamics · correlation 0.91
- Complex I / OXPHOS · correlation 0.89
- Autophagy Metabolic Stress · correlation 0.87
- BATF-driven Activation · correlation 0.86
- MHC Class II Presentation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.