SCUBA

IL2RG — Interleukin 2 receptor subunit gamma

IL2RG belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IL2RG's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsMHC-II antigen presentation
B cell maturation
ARID5A, CD52, CD74, CD79A, CTSS, CYBA, HLA-DPA1, HLA-DPB1 +9 moreView in SCUBA
CD4⁺ T cellsProteostasis OxPhos
Housekeeping
AIP, ARPC1B, ATP6V1F, C4orf48, CHMP2A, NDUFA13, NDUFB10, PPP1R7 +6 moreView in SCUBA
CD8⁺ T cellsBATF-driven Activation
T cell maturation
ARL6IP5, BATF, CD82, LAMTOR5, SCAMP2, SH2D2A, SQSTM1, SYNGR2 +2 moreView in SCUBA
EndothelialMyeloid Contamination
Cell contamination
BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 moreView in SCUBA
Gamma-delta T cellsNKG2D Cytotoxic Activation
cytotoxicity
CCND3, GABARAP, HCST, HDAC10, IER3IP1, KLRK1, KRTCAP2, LAMTOR4 +11 more
Goblet cellsDUOX2 Epithelial Inflammation
Stress
AKAP13, BIRC3, DUOX2, DUOXA2, DUSP4, IL32, ISG15, RNF213 +1 moreView in SCUBA
Innate lymphoid cellsGlycolysis & OxPhos
Metabolism
ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 moreView in SCUBA
MacrophagesIFN-gamma Response
Inflammatory
ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 moreView in SCUBA
MonocytesIFN-γ Monocyte Response
Inflammatory
ANKRD22, APOL3, ATF5, CXCL9, HAPLN3, IL2RA, LYSMD2, NFE2L3 +2 moreView in SCUBA
Natural Killer cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
ANXA6, ARPC1B, ARPC4, BAX, CAPNS1, CAPZB, GNAI2, NDUFA13 +7 moreView in SCUBA

About the gene

SynonymsCD132, CIDX, IMD4, SCIDX1
ChromosomeX: 71107404-71112108
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classCancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Molecular functionReceptor
Biological processHost-virus interaction

Function

Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.