T cell Immune Tolerance
Gene co-expression module in CD8⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
CBLB is a canonical E3 ubiquitin ligase that enforces T cell anergy and restrains TCR/CD28 signaling; its expression marks tolerance and exhaustion programs. TNFRSF1B (TNFR2) promotes regulatory/suppressive T cell function and survival. STAT3 drives IL-10/IL-6-mediated immunosuppressive and pro-survival programs. ARID5B stabilizes STAT3/IL-6 mRNA. TRAF5 modulates TNFR signaling. NAMPT sustains NAD-dependent survival. LYST regulates granule secretion but its co-expression here with tolerance genes suggests this is a broader immune regulation module. Together these genes reflect a T cell negative regulatory/immune tolerance program.
Genes
ARID5B, CBLB, DTHD1, LYST, NAMPT, STAT3, TNFRSF1B, TRAF5
Most correlated modules
- Gut Residence Trm · correlation 0.82
- CD8 Effector Maturation · correlation 0.80
- TCR Activation & Modulation · correlation 0.78
- IFN-gamma Response · correlation 0.78
- TCR Proximal Signaling · correlation 0.76
- T Cell Activation · correlation 0.74
- Actomyosin Motility · correlation 0.73
- Tc17 Survival Program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.