TRAF5 — TNF receptor associated factor 5
TRAF5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAF5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | T cell Immune Tolerance Immune regulation | ARID5B, CBLB, DTHD1, LYST, NAMPT, STAT3, TNFRSF1B | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more | |
| Mucosal-associated invariant T cell | Endosomal Actin Organization Cytoskeletal | ARHGEF2, ATF6B, CGGBP1, FUT11, IARS2, ICE2, INPP5B, SH3BP2 +7 more |
About the gene
| Synonyms | RNF84 |
|---|---|
| Chromosome | 1: 211326615-211374946 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF- kappa-B by EIF2AK2/PKR
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.