Tc17 Survival Program
Gene co-expression module in CD8⁺ T cells
| Category | Tc17 program |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
MAF is a key transcription factor for Tc17/Tr1 cells and IL-10-producing T cells. CCL20 is a Th17/Tc17-associated chemokine. MCL1 provides anti-apoptotic survival. TNFAIP3 (A20) restrains NF-κB. TNFRSF4 (OX40) is a co-stimulatory receptor. IRF1 and SAT1 contribute inflammatory and metabolic regulation. The combination of MAF+CCL20 alongside survival genes suggests a Tc17-associated regulatory program. Moderate coherence reflects some mixing of Tc17 identity (MAF, CCL20) with broader NF-κB/survival signals (MCL1, TNFAIP3, TNFRSF4).
Genes
CCL20, DDX5, IRF1, MAF, MCL1, SAT1, TNFAIP3, TNFRSF4
Most correlated modules
- T cell Immune Tolerance · correlation 0.73
- Immediate Early Response · correlation 0.72
- CD8 Effector Maturation · correlation 0.67
- Interferon-stimulated Genes · correlation 0.59
- AP-1 Early Activation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.