Actomyosin Motility
Gene co-expression module in CD8⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
ACTR2 (Arp2/3 actin nucleation), MYH9 (non-muscle myosin IIA, contractility), PPP1R12A (myosin phosphatase targeting subunit), CAPNS1 (calpain, actin remodeling), and YWHAZ (14-3-3, cytoskeletal signaling scaffold) define an actomyosin contractility and motility program. GNAI2 (Gi-alpha) couples chemokine receptors to cytoskeletal reorganization. AP2B1 mediates receptor internalization during migration. EMB and ADGRE5 (CD97) are adhesion molecules. This module represents T cell migration and cytoskeletal motility machinery, neighboring M52 which also has cytoskeletal components but is more TCR-signaling-focused.
Genes
ACTR2, ADGRE5, AP2B1, ARGLU1, CAPNS1, EMB, GNAI2, MYH9, PPP1R12A, VMP1, YWHAZ
Most correlated modules
- Chromatin RNA Processing · correlation 0.93
- Pre-mRNA Splicing · correlation 0.92
- TCR Proximal Signaling · correlation 0.92
- RNA Processing Mixed · correlation 0.90
- CD8 Effector Maturation · correlation 0.88
- Nuclear RNA Splicing · correlation 0.86
- IFN-gamma Response · correlation 0.84
- Gut Residence Trm · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.