TCR Proximal Signaling
Gene co-expression module in CD8⁺ T cells
| Category | TCR Signaling |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes LCP2 (SLP-76), PTPN22, CD3G, and PTPRA form the core of TCR proximal signaling, while ACTN4, MSN, and IVNS1ABP link the signaling complex to actin cytoskeletal anchoring. CMIP modulates T cell signaling downstream of TCR. TFRC (CD71) marks activated T cells. STK17B (DRAK2) regulates T cell apoptosis. Together these genes represent TCR complex signaling and its cytoskeletal coupling, a program active in T cell activation.
Genes
ACTN4, CD3G, CMIP, GALNT1, IVNS1ABP, LCP2, MSN, PTPN22, PTPRA, STK17B, TFRC, ZNRF1
Most correlated modules
- Actomyosin Motility · correlation 0.92
- CD8 Effector Maturation · correlation 0.89
- Gut Residence Trm · correlation 0.86
- Chromatin RNA Processing · correlation 0.84
- Pre-mRNA Splicing · correlation 0.84
- Cytotoxic Gut Effector · correlation 0.80
- TCR Activation & Modulation · correlation 0.79
- IFN-gamma Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.