IFN-gamma Response
Gene co-expression module in CD8⁺ T cells
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
The top hub genes IFI16 (innate DNA sensor/ISG), GBP5, SP140, SP100 (nuclear body ISGs), IRF2 (IFN regulatory factor), and TNFSF10 (TRAIL, interferon-induced apoptotic ligand) collectively define an interferon-gamma response program with apoptotic effector output. OPTN links innate sensing to selective autophagy. CASP3 supports the apoptosis-inducing arm. This module neighbors M43 (canonical ISG/type I IFN antiviral), and together they form a broader interferon response neighborhood; M45 is more IFN-gamma/effector-apoptosis-oriented.
Genes
CASP3, GBP5, IFI16, IRF2, OPTN, SP100, SP140, TNFSF10, WIPF1
Most correlated modules
- Autophagy Metabolic Stress · correlation 0.87
- RNA Processing Mixed · correlation 0.87
- Type I Interferon · correlation 0.86
- Interferon-stimulated Genes · correlation 0.84
- Actomyosin Motility · correlation 0.84
- Gut Residence Trm · correlation 0.82
- TCR Proximal Signaling · correlation 0.78
- T cell Immune Tolerance · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.