TNFRSF4 — TNF receptor superfamily member 4
TNFRSF4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, CTLA4, DNPH1, GBP2, IL2RA, NAMPT, NDFIP2 +6 more | View in SCUBA |
| CD8⁺ T cells | Tc17 Survival Program Tc17 program | CCL20, DDX5, IRF1, MAF, MCL1, SAT1, TNFAIP3 | View in SCUBA |
| Hematopoietic progenitor cells | Regulatory T-cell State Lymphcyte development | CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A +9 more | |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Lymphatic endothelial | Antigen Presentation IFN Inflammation | ADAR, GPRC5B, HLA-F, KTN1, PARP14, PTTG1IP, SCARB2, TAPBP +2 more | View in SCUBA |
| Pericytes | Vascular Pericyte Identity Developmental | ABCG1, ACVRL1, ATP11A, CASP10, CCM2L, CD320, GPRC5B, KL +7 more | View in SCUBA |
About the gene
| Synonyms | ACT35, CD134, OX40, TXGP1L |
|---|---|
| Chromosome | 1: 1211326-1214153 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Host-virus interaction |
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.