AP-1 Early Activation
Gene co-expression module in CD8⁺ T cells
| Category | TCR Signaling |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
The module is led by FOSB, JUNB, FOS — the canonical AP-1 immediate early gene triad — alongside BTG2, IER2, EGR1, NR4A2, and SOCS3, all classical immediate early response genes induced within minutes of TCR engagement or cellular stress. CD69 is the earliest surface marker of T cell activation, TNF is an early effector cytokine, MYADM is induced in activated myeloid/lymphoid cells, and TLE4 modulates AP-1/Wnt transcription. Together with neighbor M39 (also immediate early/NR4A1/JUN), this forms a coordinated AP-1/early activation response. The two modules likely represent slightly different time-points or intensity arms of the same immediate-early activation program. The presence of TNF and CD69 suggests this is true early activation rather than pure dissociation stress.
Genes
BTG2, CD69, EGR1, FOS, FOSB, IER2, JUNB, LEPROTL1, LITAF, MYADM, NR4A2, SOCS3, TLE4, TNF
Most correlated modules
- Immediate Early Response · correlation 0.64
- Tc17 Survival Program · correlation 0.58
- Naive/Memory CD8 · correlation 0.57
- Effector Memory CD8 · correlation 0.55
- Naive/Central Memory · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.