Complex I / OXPHOS
Gene co-expression module in CD8⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Four of the top five hub genes are NADH:ubiquinone oxidoreductase (Complex I) subunits: NDUFS6, NDUFB3, NDUFAB1, NDUFA4, NDUFA12. GSTO1 (glutathione transferase omega, oxidative stress response), TXNDC17 (thioredoxin domain, redox), MANF (ER stress/UPR neurotrophic factor), GTF3C6 (RNA Pol III transcription factor), and DAD1 (dolichyl-diphosphooligosaccharide protein glycosyltransferase, anti-apoptosis/glycosylation). The dominant signal is clearly mitochondrial Complex I / OXPHOS, with supporting redox and ER stress genes. This is a tightly defined OXPHOS module, consistent with its strong coherence. As neighbor to M71 (also OXPHOS/proteasome), these two modules represent the core mitochondrial program.
Genes
DAD1, GSTO1, GTF3C6, MANF, NDUFA12, NDUFA4, NDUFAB1, NDUFB3, NDUFS6, TXNDC17
Most correlated modules
- OxPhos & Proteasome · correlation 0.97
- Cellular Housekeeping · correlation 0.96
- Proteasome Degradation · correlation 0.96
- Mitochondrial OxPhos · correlation 0.95
- Mitochondrial Housekeeping · correlation 0.94
- ER Protein Quality Control · correlation 0.94
- RNA Splicing Complex · correlation 0.94
- RNA & Redox Housekeeping · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.