ER Protein Quality Control
Gene co-expression module in CD8⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: PSMB1, PSMA5, PSMC4 are proteasome subunits; CALR (calreticulin, ER chaperone/UPR), PPIB (cyclophilin B, ER prolyl isomerase/chaperone), PDIA3 (protein disulfide isomerase, ER quality control), TMCO1 (ER calcium channel), SRI (sorcin, calcium-binding), DYNLL1 (dynein light chain, cytoskeletal), ARPC3 (actin-related, Arp2/3), PUF60 (RNA splicing), MRPL47 (mitochondrial ribosomal). Dominant signal is ER protein quality control and proteasome-mediated protein degradation — consistent with ER stress/unfolded protein response housekeeping. The module coherence is moderate, with some peripheral cytoskeletal/RNA members. Neighbor context supports constitutive protein processing housekeeping programs.
Genes
ARPC3, CALR, DYNLL1, MRPL47, PDIA3, PPIB, PSMA5, PSMB1, PSMC4, PUF60, SRI, TMCO1
Most correlated modules
- Complex I / OXPHOS · correlation 0.94
- TCR Proximal Signaling · correlation 0.94
- Proteasome Degradation · correlation 0.93
- ER-Golgi Trafficking · correlation 0.93
- Mitochondrial OxPhos · correlation 0.92
- OxPhos & Proteasome · correlation 0.92
- RNA Splicing Complex · correlation 0.92
- Proteostasis Translation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.