SCUBA

PRDX5 — Peroxiredoxin 5

PRDX5 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PRDX5's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsCytoskeleton & metabolism
Cytoskeletal
ATP5F1D, ATP5MC3, ATP6V0E1, BRK1, CAP1, LCK, MYL6, NEDD8 +11 moreView in SCUBA
CD8⁺ T cellsTCR Proximal Signaling
TCR Signaling
CHMP2A, CSK, HCLS1, MAP2K2, MPG, NOP10, SRP14, ZNHIT1View in SCUBA
EndothelialMitochondrial Oxidative Stress
Stress
AGTRAP, AP2M1, ECHS1, ECSCR, EDF1, EIF5A, NEDD8, PARK7 +5 moreView in SCUBA
Gamma-delta T cellsMitochondrial OxPhos
Mitochondrial & OxPhos
ADSL, AP1S1, CD151, COMTD1, COX5A, DDT, DNPH1, DUSP23 +20 more
Goblet cellsAnti-inflammatory Lipid Signaling
Housekeeping
AQP1, CDCA7, FBL, IMPDH2, PTGDR, RARRES2, UGT2A3View in SCUBA
Innate lymphoid cellsActin Cytoskeleton Dynamics
Cytoskeleton & motility
ACTB, ACTG1, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB +11 moreView in SCUBA
Lymphatic endothelialHousekeeping Mixed
Housekeeping
GUK1, LAMTOR4, NDUFB11, NEDD8, RNASEH2C, SSR4, VPS28, ZNHIT1View in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos
ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4 +9 moreView in SCUBA
Smooth muscle cellsOxPhos & proteasome
Mitochondrial & OxPhos
CD151, CHCHD2, COX5B, EID1, NDUFA11, NDUFB2, NDUFB9, NEDD8 +8 moreView in SCUBA

About the gene

SynonymsACR1, AOEB166, B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10
Chromosome11: 64318121-64321811
Predicted locationIntracellular
Essential geneNo
Protein classEnzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionAntioxidant, Oxidoreductase, Peroxidase

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.