MPG — N-methylpurine DNA glycosylase
MPG belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MPG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Actin Cytoskeleton Cytoskeletal | COTL1, GNAI2, HIGD2A, MOB1A, MYL12A, MYL12B, NDUFB5, PRR13 +8 more | View in SCUBA |
| CD4⁺ T cells | mRNA stability regulation Immune regulation | APLP2, ARID5B, CARHSP1, GK, GLCCI1, GRAMD4, HIVEP1, METTL8 +12 more | View in SCUBA |
| CD8⁺ T cells | TCR Proximal Signaling TCR Signaling | CHMP2A, CSK, HCLS1, MAP2K2, NOP10, PRDX5, SRP14, ZNHIT1 | View in SCUBA |
| Fibroblasts | ER-Golgi Trafficking Vesicular traficking | ARL1, CALR, COPE, DNAJC3, EMC7, GDI2, MYDGF, PDIA6 +6 more | View in SCUBA |
| Gamma-delta T cells | DNA Repair Housekeeping Housekeeping | ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, ERCC1 +10 more | |
| Innate lymphoid cells | ILC-1 identity Differentiation | ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3 +20 more | View in SCUBA |
| Natural Killer cells | Resident NK cells Gut residency | ANXA11, APBB1IP, CD151, CXXC5, HMOX2, LSP1, PPDPF, SH3BP1 +4 more | View in SCUBA |
About the gene
| Synonyms | MDG |
|---|---|
| Chromosome | 16: 77007-85851 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
| Biological process | DNA damage, DNA repair |
Function
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.