ER-Golgi Trafficking
Gene co-expression module in CD8⁺ T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include COPZ1 and COPE (COPI vesicle coat proteins involved in Golgi-ER retrograde transport), SURF4 (ER cargo receptor), VCP (AAA-ATPase for ER-associated degradation and membrane trafficking), BLOC1S1 (biogenesis of lysosome-related organelles), CLIC1 (chloride channel, ER/membrane associated), MYL6 (myosin light chain), IFI27L2 (interferon-stimulated), RAP1B (small GTPase, vesicle/integrin signaling), FIBP (FGF-binding/ER). The dominant theme is ER-to-Golgi vesicular transport/protein secretory pathway. IFI27L2 is a modest outlier. Coherence is moderate, reflecting a mixed but related ER trafficking/protein processing program. Neighbors M34 and M47 also represent constitutive housekeeping/protein processing programs.
Genes
BLOC1S1, CLIC1, COPE, COPZ1, FIBP, IFI27L2, MYL6, RAP1B, SURF4, VCP
Most correlated modules
- Actin Cytoskeleton Dynamics · correlation 0.95
- TCR Proximal Signaling · correlation 0.94
- ER Protein Quality Control · correlation 0.93
- Proteasome Degradation · correlation 0.93
- Mitochondrial OxPhos · correlation 0.93
- IFN-gamma Stress Response · correlation 0.92
- Vesicle Trafficking · correlation 0.92
- Rho GTPase Cytoskeletal · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.