Mitochondrial OxPhos
Gene co-expression module in CD8⁺ T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include COX6C, COX7B, COX6B1, COX7A2 (cytochrome c oxidase subunits), NDUFB2 (NADH:ubiquinone oxidoreductase), UQCR10, UQCRH (ubiquinol-cytochrome c reductase subunits) — all core mitochondrial respiratory chain components. ELOB (elongin B, involved in ubiquitin-proteasome pathway), UBL5 (ubiquitin-like), POMP (proteasome maturation), SEM1 (proteasome regulatory particle), LSM7 (RNA splicing), SRSF9 (splicing factor), DBI (mitochondria-associated lipid transport) are peripheral. The dominant signal is oxidative phosphorylation/mitochondrial electron transport chain. Uniform expression across subsets. Neighbor context: sits near housekeeping/metabolic modules (M88, M47), consistent with constitutive metabolic housekeeping rather than a cell-state-specific program.
Genes
COX6B1, COX6C, COX7A2, COX7B, DBI, ELOB, LSM7, NDUFB2, POMP, SEM1, SRSF9, UBL5, UQCR10, UQCRH
Most correlated modules
- Proteasome Degradation · correlation 0.96
- Cellular Housekeeping · correlation 0.96
- RNA Splicing Complex · correlation 0.96
- Complex I / OXPHOS · correlation 0.95
- IFN-gamma Stress Response · correlation 0.94
- Mitochondrial ETC/OxPhos · correlation 0.93
- ER-Golgi Trafficking · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.