ER Protein Folding
Gene co-expression module in Hematopoietic progenitor cells
| Category | Housekeeping |
|---|---|
| Genes | 22 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include SEC11A (signal peptidase complex), SEC61B (ER translocon), PDIA3/PDIA6/P4HB (protein disulfide isomerases), PPIB (cyclophilin B), CALR (calreticulin), HSPA5 (BiP/GRP78), and MLEC (malectin) — all canonical ER protein folding and quality control components. CHPT1 and PLIN2 add lipid metabolic context. This is a tightly coherent ER protein processing/secretory pathway module expressed broadly (housekeeping).
Genes
ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2, MLEC, P4HB, PDIA3, PDIA6, PLGRKT, PLIN2, PPIB, S100A4, S100A6, SEC11A, SEC61B, SND1, SRGN, SYNGR2
Most correlated modules
- Hematopoietic Progenitor Identity · correlation 0.89
- Proteostasis & OxPhos · correlation 0.79
- HPC Stemness Program · correlation 0.76
- Myeloid Lipid Signaling · correlation 0.75
- Chaperonin TRiC Complex · correlation 0.71
- Chromatin Remodeling · correlation 0.71
- Mast Cell Progenitor · correlation 0.69
- RNA Processing Housekeeping · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.