HPC Stemness Program
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 12 genes have a known function matching the annotation |
Why this annotation
CITED2 is a critical regulator of HSC self-renewal and quiescence. HBS1L is linked to hematopoietic stem/progenitor regulation (HBS1L-MYB locus). CSF2RB encodes the common beta chain of GM-CSF/IL-3/IL-5 receptors, expressed on myeloid progenitors. FBXO7 is involved in hematopoietic progenitor maintenance. CASP3 marks apoptotic priming. The combination of CITED2+HBS1L+CSF2RB in a core-coherence module suggests an HPC stemness/early myeloid priming program. Neighbor context (mast cell modules) is consistent with broad myeloid progenitor neighborhood.
Genes
AMHR2, ARMC8, CASP3, CITED2, CNRIP1, CSF2RB, DLC1, FBXO7, HBS1L, KCNH2, RYR3, TP53RK
Most correlated modules
- Myeloid Lipid Signaling · correlation 0.86
- Mast Cell Progenitor · correlation 0.83
- Erythroid Progenitor Program · correlation 0.81
- Mast Cell Differentiation · correlation 0.80
- Hematopoietic Progenitor Identity · correlation 0.79
- Chromatin Remodeling · correlation 0.76
- ER Protein Folding · correlation 0.76
- Eosinophil Differentiation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.