Myeloid Lipid Signaling
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
This small, low-expression module contains CLEC12A (myeloid inhibitory receptor on myeloid progenitors/monocytes), PLD1 (phospholipase D, involved in mast cell/basophil degranulation and lipid signaling), SGPP1 (sphingosine-1-phosphate phosphatase, lipid signaling), GALC (galactocerebrosidase, lipid catabolism), and AFF2 (transcriptional regulator). The module sits near mast cell modules. The combination of CLEC12A and lipid metabolism genes (PLD1, SGPP1, GALC) suggests a myeloid/mast cell lipid signaling program, though the module is mixed and has very low expression (4%).
Genes
AFF2, CLEC12A, GALC, PLD1, SGPP1, SLC24A3, TENT5A, TEX9
Most correlated modules
- Mast Cell Differentiation · correlation 0.92
- Eosinophil Differentiation · correlation 0.89
- HPC Stemness Program · correlation 0.86
- Mast Cell Progenitor · correlation 0.83
- Mast Cell Basophil · correlation 0.81
- ER Protein Folding · correlation 0.75
- Hematopoietic Progenitor Identity · correlation 0.68
- Chromatin Remodeling · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.