Mast Cell Progenitor
Gene co-expression module in Hematopoietic progenitor cells
| Category | Granulocyte development |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub genes define a mast cell/basophil progenitor state: HPGDS (hematopoietic prostaglandin D synthase, mast cell marker), GATA2 (key mast cell transcription factor), CPA3 (mast cell carboxypeptidase A3, canonical mast cell marker), IKZF2 (Helios, expressed in mast cells and basophils), CD84 (mast cell surface marker), and NLK. This cluster sits in a neighborhood with M28 and M52 which also show mast cell signatures, confirming this represents early mast cell commitment within HPCs.
Genes
CD84, CPA3, FRY, GATA2, HPGDS, IKZF2, NLK, REXO5, RRBP1, SLC45A3, SVOPL
Most correlated modules
- Myeloid Lipid Signaling · correlation 0.83
- HPC Stemness Program · correlation 0.83
- Erythroid Progenitor Program · correlation 0.80
- Mast Cell Differentiation · correlation 0.78
- Hematopoietic Progenitor Identity · correlation 0.77
- HSC Progenitor Proliferation · correlation 0.75
- Mast Cell Basophil · correlation 0.73
- Eosinophil Differentiation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.