T/NK Cell Identity
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes LCP1 (L-plastin, lymphocyte actin bundler), CD53 (leukocyte tetraspanin), SATB1 (T-cell genome organizer), NKG7 (cytotoxic lymphocyte granule protein), TRAF3IP3 (T-cell TRAF signaling adapter), PREX1 (Rac GEF active in lymphocytes), ATM (DNA damage/lymphocyte development), and RASSF2 (Ras effector in T-cells) form a tight lymphocyte identity signature. The module is coherent with core/strong memberships throughout. Neighbor M70 reinforces a broader lymphocyte program in this network neighborhood.
Genes
ATM, BAZ2B, CD53, LCP1, LGMN, MED13L, NKG7, PREX1, RASSF2, SATB1, SLC38A1, TRAF3IP3
Most correlated modules
- Lymphoid Progenitor TFs · correlation 0.93
- Regulatory T-cell State · correlation 0.90
- Naive B Cell · correlation 0.89
- Lymphocyte Signaling · correlation 0.88
- HOX HSC Program · correlation 0.79
- MHC-I Antigen Presentation · correlation 0.78
- Myeloid Commitment · correlation 0.77
- Multipotent Progenitor Identity · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.