ILC3/γδT Priming
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 17 genes have a known function matching the annotation |
Why this annotation
This module is dominated by T-cell and innate-like lymphocyte markers: RORC (RORγt, master transcription factor for ILC3/Th17/γδT cells), TRDC (TCR delta chain, γδ T cells), TRAC (TCR alpha chain), CD7 (pan T/ILC marker), CD2 (T/NK marker), MAF (Th2/ILC transcription factor), TOX2 (lymphocyte transcription factor), CCR1 (lymphocyte chemokine receptor), FGR (Src-family kinase in lymphoid cells), GPR18 (NK/ILC receptor), CCL1 (T-cell chemokine), CHI3L2 (expressed in lymphoid cells), IL17RE and LINGO4 (ILC/T-cell associated). The co-expression of RORC with TRDC/TRAC strongly points to γδ T cell or ILC3 priming from HPC. As a neighbor of M7 (myeloid innate), this module represents the lymphoid branch of innate-like lymphocyte development from HPCs.
Genes
C2CD4D, CCL1, CCR1, CD2, CD7, CHI3L2, FGR, GPR18, IL17RE, LINGO4, MAF, PTH1R, RORC, SRPK3, TOX2, TRAC, TRDC
Most correlated modules
- ILC/NK Development · correlation 0.87
- Lymphocyte Signaling · correlation 0.69
- Regulatory T-cell State · correlation 0.65
- Dendritic Cell Progenitor · correlation 0.62
- MHC-I Antigen Presentation · correlation 0.58
- Myeloid Innate Immune · correlation 0.57
- T/NK Cell Identity · correlation 0.51
- ILC2-like State · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.