Hematopoietic Progenitor Identity
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: MTHFD2 (mitochondrial folate/one-carbon metabolism, highly upregulated in proliferating and differentiating hematopoietic cells), DAD1 (defender against apoptosis, part of oligosaccharyltransferase complex), HSH2D (hematopoietic SH2 domain-containing, expressed in lymphoid/myeloid progenitors), HYAL3 (hyaluronidase), CD38 (ectoenzyme, calcium signaling, marker of early hematopoietic progenitors and plasma cells), KIT (stem cell factor receptor, canonical HPC marker), PTPN7 (hematopoietic-restricted tyrosine phosphatase), ITGAE (integrin alpha-E, expressed on tissue-resident lymphoid cells and some progenitors), PARVB (parvin beta, cytoskeletal). The co-expression of KIT and CD38 along with MTHFD2 and PTPN7 strongly anchors this module to early HPC identity/stemness with active one-carbon metabolic reprogramming. The module is uniformly expressed at low levels, fitting a rare progenitor state.
Genes
CD38, DAD1, HSH2D, HYAL3, ITGAE, KIT, MBOAT2, MTHFD2, PARVB, PTPN7, SRI
Most correlated modules
- ER Protein Folding · correlation 0.89
- Replication Stress Response · correlation 0.82
- Chromatin Remodeling · correlation 0.80
- HPC Stemness Program · correlation 0.79
- HSC Progenitor Proliferation · correlation 0.78
- Proteostasis & OxPhos · correlation 0.78
- Chaperonin TRiC Complex · correlation 0.78
- Erythro-Megakaryocytic Development · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.