Chromatin Remodeling
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes: EIF3A (translation initiation, eIF3 complex), RIF1 (replication timing, DNA repair, chromatin organization), SMARCC1 (SWI/SNF chromatin remodeling complex, transcriptional regulation of stemness and differentiation), USP48 (deubiquitinase, chromatin regulation), RFX7 (transcription factor, regulates quiescence and metabolism in lymphocytes/progenitors), HNRNPM (RNA splicing), EIF5B (translation initiation GTPase), CBX3 (HP1 gamma, heterochromatin), SYNCRIP (RNA binding, hnRNP-Q), TOP2B (topoisomerase II beta, transcription-coupled DNA topology), GDF11 (TGF-beta family ligand, developmental). The module combines chromatin remodeling (SMARCC1, CBX3, RIF1), transcription factor activity (RFX7), and translational control (EIF3A, EIF5B, HNRNPM, SYNCRIP), consistent with a gene regulatory/chromatin remodeling program active in progenitor cells. The neighbor context (cell cycle module M14, housekeeping M38) supports this being a proliferation-coupled chromatin regulation program.
Genes
CBX3, EIF3A, EIF5B, GDF11, HNRNPM, NMNAT3, RFX7, RIF1, SMARCC1, SYNCRIP, TOP2B, TRAPPC6B, USP48
Most correlated modules
- Replication Stress Response · correlation 0.90
- DNA Damage Repair · correlation 0.83
- HSC Progenitor Proliferation · correlation 0.83
- Ribosome Biogenesis · correlation 0.81
- Erythroid Progenitor Program · correlation 0.81
- Hematopoietic Progenitor Identity · correlation 0.80
- HPC Stemness Program · correlation 0.76
- Erythroid Differentiation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.