TENT5A — Terminal nucleotidyltransferase 5A
TENT5A belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TENT5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Type I Interferon Anti-viral | GBP2, GBP4, IRF9, ISG15, ISG20, LY6E, MNDA, MX1 +9 more | View in SCUBA |
| CD4⁺ T cells | Hypoxia metabolic stress Stress | ARG2, ARL4D, AXIN2, BNIP3, CITED4, CNKSR2, GCA, GSTM3 +13 more | View in SCUBA |
| Gamma-delta T cells | Lysosomal Biogenesis Protein processing & ER | ABI3, APLP2, ATP10A, B3GALT4, BAX, CD63, CTNNA1, DOCK5 +14 more | |
| Goblet cells | Hypoxia Metabolic Stress Stress | ADGRE5, ANKRD37, ARL4A, FBXO32, IRS2, KLF2, LRRFIP1, SKIL | View in SCUBA |
| Hematopoietic progenitor cells | Myeloid Lipid Signaling Myeloid development | AFF2, CLEC12A, GALC, PLD1, SGPP1, SLC24A3, TEX9 | |
| Innate lymphoid cells | Dissociation Stress Response Stress | C12orf57, CA2, CALM2, EHD1, EIF4A2, IER2, MEPCE, NDRG1 +9 more | View in SCUBA |
| Macrophages | Myeloid Signaling Regulation Innate immunity | ADGRG6, AOAH, CCDC170, CD302, CMKLR1, CPED1, DIPK2A, FAM13A +38 more | View in SCUBA |
About the gene
| Synonyms | C6orf37, FAM46A, FLJ20037 |
|---|---|
| Chromosome | 6: 81491439-81752774 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Nucleotidyltransferase, Transferase |
Function
Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation. Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.