ILC1 Effector Activation
Gene co-expression module in Innate lymphoid cells
| Category | activation |
|---|---|
| Genes | 25 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Weak coherence module with heterogeneous membership. Hub genes include TNFSF10 (TRAIL, cytotoxic ligand), TAP1 (antigen processing/MHC-I loading), BATF (ILC1/effector TF), PIM1 (survival/activation kinase), NCF4 (NADPH oxidase component), ADAM19 (metalloprotease), and PFKL (glycolysis). Multiple genes are enriched in ILC1 (BATF, ADAM19, PIM1, NCF4, UNC119, PFKL, ARHGEF3, PLPP1), suggesting an ILC1-biased effector/activation state. TNFSF10 and TAP1 point toward cytotoxic and innate immune effector functions. The module is mixed but the dominant signal is ILC1 innate effector activation. Neighbor M65 also shows ILC1/ILC3 enrichment, supporting a shared ILC activation context.
Genes
ADAM19, ARHGEF3, BATF, CD151, CDK4, FES, FURIN, HLA-F, IL22, MLF2, NCF4, NOTCH2, OTUD5, PFKL, PIM1, PLPP1, STAG2, STK17B, STOM, TAP1, TNFSF10, TYMP, UNC119, USP15, ZNRF1
Most correlated modules
- Antigen Processing MHC-I · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.