Antigen Processing MHC-I
Gene co-expression module in Innate lymphoid cells
| Category | Immune regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include IL2RB (NK/ILC identity receptor), YWHAB (14-3-3 signaling scaffold), PSMA5/PSMB8/PSMB9 (proteasome subunits), MYL12A (myosin light chain, cytoskeletal), S100A11 (calcium-binding), TAPBP (tapasin, MHC-I antigen loading), and CMTM6 (PD-L1 stabilizer). The module is ILC1-enriched and moderate coherence, combining NK identity/surface markers with proteasome activity. The dominant theme across hub genes is antigen processing and NK cell identity, with TAPBP and PSMB8/9 (immunoproteasome subunits) pointing to MHC-I antigen presentation machinery. This links to the proteasome-heavy neighbors M74 and M62.
Genes
CMTM6, GUK1, IL2RB, IL4R, MYL12A, PAXX, PSMA5, PSMB8, PSMB9, S100A11, SDHD, SH3BGRL3, SPPL2A, TAPBP, TPM3, XRN2, YWHAB
Most correlated modules
- Endosomal Trafficking Signaling · correlation 0.92
- DNA Damage Response · correlation 0.91
- NK JAK3 Signaling · correlation 0.90
- Actin Cytoskeleton Dynamics · correlation 0.87
- ILC1 Effector Activation · correlation 0.87
- Innate Inflammatory Activation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.