NOTCH2 — Notch receptor 2
NOTCH2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOTCH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATP2B4, ATXN1, DR1, GDE1, GNA15, GRAMD1B, GTDC1 +8 more | View in SCUBA |
| Enterocytes | Secretory progenitor Notch Epithelial development | ADAMTS14, ADCY5, ADGRG4, DOCK8, HEPACAM2, MEIS1, NBPF14, NBPF19 +5 more | View in SCUBA |
| Goblet cells | Notch Secretory Specification Epithelial development | EDN1, EREG, FKBP1A, GPRC5C, HES4, HES5, MYC, PDGFA +4 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Effector Activation activation | ADAM19, ARHGEF3, BATF, CD151, CDK4, FES, FURIN, HLA-F +16 more | View in SCUBA |
| Macrophages | mRNA Splicing Processing Housekeeping | ACIN1, ARID3A, BOD1L1, CCNL2, CDK12, CLK4, DCP2, GPATCH2L +20 more | View in SCUBA |
About the gene
| Chromosome | 1: 119911553-120100779 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Activator, Developmental protein, Receptor |
| Biological process | Differentiation, Notch signaling pathway, Transcription, Transcription regulation |
Function
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.