SCUBA

STK17B — Serine/threonine kinase 17b

STK17B belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

STK17B's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsT Cell Signaling
B cell help
CCDC6, EFNB2, ELMO1, ETS1, MYO5A, PTPN11, RABGAP1L, SFXN1 +4 moreView in SCUBA
CD8⁺ T cellsTCR Proximal Signaling
TCR Signaling
ACTN4, CD3G, CMIP, GALNT1, IVNS1ABP, LCP2, MSN, PTPN22 +3 moreView in SCUBA
EnterocytesMature enterocyte differentiation
Absorption
ABCC2, ACSF2, AOC1, CDC14A, CEP350, EEPD1, EPS8L2, GRAMD1C +5 moreView in SCUBA
Gamma-delta T cellsPre-mRNA Splicing
RNA processing & translation
BCLAF1, CENPC, CLK1, CNOT1, COG3, COPS2, DDX24, DDX3X +11 more
Hematopoietic progenitor cellsRegulatory T-cell State
Lymphcyte development
CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A +9 more
Innate lymphoid cellsILC1 Effector Activation
activation
ADAM19, ARHGEF3, BATF, CD151, CDK4, FES, FURIN, HLA-F +16 moreView in SCUBA
MacrophagesAutophagy Vesicle Trafficking
Lysosomal & pahgocytosis
ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 moreView in SCUBA
Mucosal-associated invariant T cellER Stress UPR
Stress
DDIT3, DNAJB9, EIF4A1, GTF2B, HERPUD1, HNRNPA0, IDI1, LDHA +9 more
Natural Killer cellsTGF-β Antagonism
Immune regulation
IFRD1, IRS2, MOB3A, RBM39, SBDS, SMAD7, SRSF5, ZBTB1 +1 moreView in SCUBA
NeutrophilsUbiquitin-Proteasome Turnover
Housekeeping
BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, IL18RAP, KIF13A +10 more

About the gene

SynonymsDRAK2
Chromosome2: 196133583-196176503
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classEnzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis

Function

Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.