ZNRF1 — Zinc and ring finger 1
ZNRF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZNRF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytoskeleton & metabolism Cytoskeletal | ATP5F1D, ATP5MC3, ATP6V0E1, BRK1, CAP1, LCK, MYL6, NEDD8 +11 more | View in SCUBA |
| CD8⁺ T cells | TCR Proximal Signaling TCR Signaling | ACTN4, CD3G, CMIP, GALNT1, IVNS1ABP, LCP2, MSN, PTPN22 +3 more | View in SCUBA |
| Endothelial | TRAIL-mediated Apoptosis Stress | CLDN15, ELOVL7, EVA1C, FGD4, ISCU, LMCD1, SELENOM, TIMMDC1 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Effector Activation activation | ADAM19, ARHGEF3, BATF, CD151, CDK4, FES, FURIN, HLA-F +16 more | View in SCUBA |
About the gene
| Synonyms | DKFZp434E229, FLJ14846, nin283 |
|---|---|
| Chromosome | 16: 74999024-75110994 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that plays a role in different processes including cell differentiation, receptor recycling or regulation of inflammation. Mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Controls ligand-induced EGFR signaling via mediating receptor ubiquitination and recruitment of the ESCRT machinery. Acts as a negative feedback mechanism controlling TLR3 trafficking by mediating TLR3 'Lys-63'-linked polyubiquitination to reduce type I IFN production. Modulates inflammation by promoting caveolin-1/CAV1 ubiquitination and degradation to regulate TLR4-activated immune response.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.