Innate Stress Signaling
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 16 genes have a known function matching the annotation |
Why this annotation
MAP2K6 (MKK6, direct activator of p38 MAPK), IFI16 (innate DNA sensor activating inflammatory signaling), TIFA (TRAF-interacting protein activating NF-kB/innate immunity), TAGAP (T/NK cell activation GTPase), and RGS2 (G-protein regulator downstream of immune activation) collectively point to innate immune stress/activation signaling. KIF5B and RDX add cytoskeletal components. PLIN2 suggests lipid droplet formation under stress. ILC1 enrichment of IFI16, MAP2K6, TIFA is consistent with ILC1 inflammatory state. Moderate coherence with weak memberships reflects a mixed but inflammation-associated program.
Genes
C19orf25, DNAJC15, IFI16, KIF5B, KRCC1, MAP2K6, PCMTD1, PLIN2, RALBP1, RDX, RGS2, SLTM, TAGAP, TERF1, TIFA, UPF2
Most correlated modules
- Pyruvate Metabolism · correlation 0.92
- Mitochondrial Housekeeping · correlation 0.89
- Innate Inflammatory Activation · correlation 0.89
- RNA-binding & Splicing · correlation 0.87
- Centrosome & Scaffolding · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.