TAGAP — T cell activation RhoGTPase activating protein

TAGAP belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TAGAP's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	BCR Signaling Regulation BCR/AP1/NFKb pathway	CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP +5 more	View in SCUBA
CD4⁺ T cells	Integrin Adhesion Migration migration & adhesion	ARAP2, ATF7IP, C4orf3, CLEC2B, COTL1, CTSH, DEK, DIAPH1 +11 more	View in SCUBA
CD8⁺ T cells	Effector-Memory CD8 T cell maturation	CD27, CD44, CMC1, CST7, CXCR3, DUSP2, EOMES, F2R +8 more	View in SCUBA
Endothelial	Macrophage Contamination Cell contamination	CCDC68, CLEC7A, CORO2A, CPVL, DIXDC1, DOCK11, LPCAT4, PTGS1 +3 more	View in SCUBA
Gamma-delta T cells	NK/T Cell Identity T cell maturation	AFTPH, ARHGAP17, ASXL2, ATF7IP, CALCOCO2, CD244, CLK3, GDI1 +24 more
Innate lymphoid cells	Innate Stress Signaling Inflammation	C19orf25, DNAJC15, IFI16, KIF5B, KRCC1, MAP2K6, PCMTD1, PLIN2 +7 more	View in SCUBA
Macrophages	Anti-inflammatory Response Inflammatory	AMPD2, ARRDC2, BHLHE40, CBX4, CDKN1B, CEBPD, CITED2, DENND3 +31 more	View in SCUBA
Monocytes	Immediate-Early Inflammatory Inflammatory	CXCL2, CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIA, NFKBIZ +3 more	View in SCUBA
Neutrophils	NF-κB Activation Inflammatory	EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLAUR, PLEK +6 more

About the gene

Synonyms	ARHGAP47, FLJ32631, IDDM21
Chromosome	6: 159034468-159045152
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	GTPase activation, Guanine-nucleotide releasing factor

Function

May function as a GTPase-activating protein and may play important roles during T-cell activation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.