DNAJC15 — DnaJ heat shock protein family (Hsp40) member C15
DNAJC15 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJC15's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Oxidative Stress Stress | ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS +13 more | View in SCUBA |
| Gamma-delta T cells | Metabolic Housekeeping Housekeeping | ACAP1, ANTKMT, ATP6V0E2, B3GAT3, CCDC57, CHN2, CMTM3, DCTD +12 more | |
| Innate lymphoid cells | Innate Stress Signaling Inflammation | C19orf25, IFI16, KIF5B, KRCC1, MAP2K6, PCMTD1, PLIN2, RALBP1 +7 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC8, ENY2 +28 more | View in SCUBA |
About the gene
| Synonyms | DNAJD1, MCJ |
|---|---|
| Chromosome | 13: 43023203-43114213 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Predicted membrane proteins |
| Molecular function | Chaperone |
| Biological process | Protein transport, Translocation, Transport |
Function
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.