RALBP1 — RalA binding protein 1
RALBP1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RALBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA Processing RNA processing | ABI1, AGFG1, CCND3, CD164, CHMP2B, DBF4, GHITM, HNRNPL +9 more | View in SCUBA |
| Endothelial | ER-Golgi Trafficking Protein processing & ER | ARPC1A, CCT8, FIBP, GDI2, GGCT, LMAN2, MAP2K2, MRPS16 +10 more | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CDK2AP2, CHMP1A, COA6, CYB5B, ELOVL1, GNG5, HADHB +11 more | |
| Innate lymphoid cells | Innate Stress Signaling Inflammation | C19orf25, DNAJC15, IFI16, KIF5B, KRCC1, MAP2K6, PCMTD1, PLIN2 +7 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Metabolism & Redox Mitochondrial & OxPhos | ATP5PF, CHURC1, DAD1, DHRS7, EGLN2, HMOX2, ITM2B, MRPS21 +7 more | |
| Smooth muscle cells | Actomyosin Regulation Contractility | ARID5A, ASAH1, CAP2, COX6A2, DMTN, GABRA4, HAPLN2, NAPA +6 more | View in SCUBA |
About the gene
| Synonyms | RIP, RIP1, RLIP76 |
|---|---|
| Chromosome | 18: 9475009-9538114 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins, Transporters |
| Molecular function | GTPase activation, Translocase |
| Biological process | Transport |
Function
Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L. Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.