Pyruvate Metabolism
Gene co-expression module in Innate lymphoid cells
| Category | Metabolism |
|---|---|
| Genes | 19 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 19 genes have a known function matching the annotation |
Why this annotation
MPC2 (mitochondrial pyruvate carrier) and PDHA1 (pyruvate dehydrogenase E1-alpha) are strong metabolic hub genes pointing to mitochondrial pyruvate oxidation. ARID1B and PHIP are chromatin remodelers that may co-regulate metabolic gene expression. EIF2AK2/PKR links to metabolic stress sensing. ABCB1 and ADI1 (methionine salvage) add metabolic flavor. ILC1 enrichment of several genes is consistent with ILC1 metabolic state. Moderate coherence with many weak memberships suggests a mixed module anchored by pyruvate metabolism.
Genes
ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2, MPC2, PCF11, PDHA1, PHIP, SKAP2, SMIM7, SS18L2, TRA2B, TTC39C, USP8, ZBTB20
Most correlated modules
- Innate Stress Signaling · correlation 0.92
- Pre-mRNA Splicing · correlation 0.90
- RNA-binding & Splicing · correlation 0.89
- Endosomal Trafficking · correlation 0.89
- mRNA Stability & Splicing · correlation 0.87
- Golgi RNA Processing · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.