Innate Inflammatory Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub genes include BST2 (tetherin, an interferon-stimulated gene and innate immune effector), TNFSF13B (BAFF, a cytokine involved in B-cell survival and inflammation), CD2 (T/NK cell adhesion molecule), HMGB1 (alarmin/DAMP released during inflammation), and CD63 (lysosomal/exosomal marker). The module shows a significant positive delta_inflammation signal. BST2 and TNFSF13B are well-established interferon/inflammatory response genes. HMGB1 is a canonical DAMP. ITM2B is involved in membrane trafficking and has roles in stress responses. SEC62 is an ER translocon component. The ILC1 enrichment of several genes (BST2, CD2, TNFSF13B, ARL6IP5) is consistent with an NK/ILC1 inflammatory activation state. The module coherence is moderate, reflecting a mixed but inflammation-centered program. The significant delta_inflammation score supports an inflammatory activation signature. MGST3 (glutathione transferase) and FTL (ferritin light chain) add a mild stress/oxidative component. Overall, the dominant theme is innate immune/inflammatory activation with DAMP and cytokine signaling.
Genes
ARL6IP5, BST2, CD2, CD63, FTL, HMGB1, ITM2B, MGST3, MTDH, N4BP2L2, NUDT14, SEC62, SEM1, SMAP1, TNFSF13B, TRIR
Most correlated modules
- Endosomal Trafficking Signaling · correlation 0.91
- Protein Biogenesis & Import · correlation 0.91
- Innate Stress Signaling · correlation 0.89
- ER-Golgi Trafficking · correlation 0.88
- Antigen Processing MHC-I · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.