TIFA — TRAF interacting protein with forkhead associated domain
TIFA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIFA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Activation Inflammation | C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBIA, NFKBID, PMAIP1 +5 more | View in SCUBA |
| Innate lymphoid cells | Innate Stress Signaling Inflammation | C19orf25, DNAJC15, IFI16, KIF5B, KRCC1, MAP2K6, PCMTD1, PLIN2 +7 more | View in SCUBA |
| Lymphatic endothelial | DNA Damage Autophagy Stress | CKS2, COQ10B, GADD45A, HBP1, MAP1LC3B, MSX1, NR1D1, PHLDA2 +2 more | View in SCUBA |
About the gene
| Synonyms | MGC20791, T2BP, T6BP, TIFAA |
|---|---|
| Chromosome | 4: 112272968-112285955 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Immunity, Innate immunity |
Function
Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero- beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram- negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF- kappa-B signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.