SLTM — SAFB like transcription modulator
SLTM belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLTM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | ANKRD11, BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A +12 more | View in SCUBA |
| Gamma-delta T cells | Spliceosome Regulation RNA processing & translation | AFF1, ATOSA, CEP95, CSNK1A1, FAM13B, KANSL3, KIF5B, MYSM1 +15 more | |
| Innate lymphoid cells | Innate Stress Signaling Inflammation | C19orf25, DNAJC15, IFI16, KIF5B, KRCC1, MAP2K6, PCMTD1, PLIN2 +7 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
About the gene
| Synonyms | FLJ13213, Met |
|---|---|
| Chromosome | 15: 58879050-58933679 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor, RNA-binding |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.