Mitochondrial OxPhos
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes PARK7 (DJ-1, mitochondrial oxidative stress sensor and mitophagy regulator), MRPL51 (mitochondrial ribosomal protein), ATP5F1D (ATP synthase subunit delta), VDAC1 (voltage-dependent anion channel, outer mitochondrial membrane), NDUFB11 (NADH:ubiquinone oxidoreductase, Complex I) are all core/strong mitochondrial components. NOP10 (ribosome biogenesis) and PSMB3 (proteasome) are additional housekeeping components. The module is strongly enriched for mitochondrial function with PARK7 adding an oxidative stress/mitophagy dimension. Strong coherence and ILC1 enrichment support a genuine mitochondrial program in NK/ILC1 cells.
Genes
ATP5F1D, CAP1, MRPL51, NDUFB11, NOP10, PARK7, POLR2F, PSMB3, VDAC1
Most correlated modules
- Mitochondrial OxPhos Biogenesis · correlation 0.96
- Proteasome & COPI Trafficking · correlation 0.96
- Glycolysis & OxPhos · correlation 0.95
- Mitochondrial Lysosomal Housekeeping · correlation 0.95
- Actin Cytoskeleton Remodeling · correlation 0.95
- Mixed Proteostasis Metabolism · correlation 0.95
- Actin Cytoskeleton Dynamics · correlation 0.95
- Mitochondrial Metabolism · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.