Actin Cytoskeleton Dynamics
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
The top hub genes are PFN1 (profilin-1), CAPZB (capping protein beta), ACTG1 (gamma-actin), ACTB (beta-actin), RHOC (Rho GTPase C), ACTR3 (Arp3), and ARPC5 (Arp2/3 complex subunit) — all core actin cytoskeleton regulators involved in filament polymerization, branching, and dynamics. AP2S1 is involved in clathrin-mediated endocytosis (actin-linked). PPP1CA (protein phosphatase 1) regulates actin and myosin. TPI1 and LDHA are glycolytic enzymes that co-purify with the cytoskeleton. CALM3 (calmodulin) regulates actin-myosin dynamics. PPIA (cyclophilin A) is a chaperone with actin-binding roles. NDUFS8 and PRDX5 are peripheral members. The module is strongly enriched in ILC1 (3-4x), which are tissue-resident ILC1s known for cytoskeletal remodeling. This is a tight actin cytoskeleton/motility module. Neighbor context: M63, M71, M75 all share ILC1 enrichment and metabolic/structural programs, consistent with a coordinated ILC1 housekeeping/motility network.
Genes
ACTB, ACTG1, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB, LDHA, LMAN2, NDUFS8, NSMCE1, PFN1, PPIA, PPP1CA, PRDX5, RCN2, RHOC, TPI1, TRAPPC1
Most correlated modules
- Proteasome & COPI Trafficking · correlation 0.97
- Glycolysis & OxPhos · correlation 0.97
- Glycolysis & OxPhos · correlation 0.95
- Mitochondrial Lysosomal Housekeeping · correlation 0.95
- ILC-1 identity · correlation 0.95
- Mitochondrial OxPhos · correlation 0.95
- Mitochondrial OxPhos · correlation 0.95
- ILC1 Inflammatory Activation · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.