Proteasome & COPI Trafficking
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
PSMB2 and PSMB6 are proteasome beta subunits (20S core). CCT8 is a chaperonin subunit (TRiC/CCT complex). COPE and COPZ1 are COPI vesicle coat proteins involved in ER-Golgi trafficking. MDH1 is malate dehydrogenase (TCA cycle). COX5A is cytochrome c oxidase subunit Va (complex IV). NDUFC2 and NDUFS7 are complex I subunits. GPX4 is glutathione peroxidase 4 (ferroptosis defense). LAMTOR4 is a lysosomal mTORC1 scaffold. TKT is transketolase (pentose phosphate pathway). FIBP is an FGF-binding protein. TCEA1 is a transcription elongation factor. The module combines proteasome, COPI trafficking, and mitochondrial ETC — a mixed metabolic/protein processing module. The proteasome and COPI components are the most coherent sub-program. Neighbor context supports a housekeeping/metabolic ILC1 program.
Genes
CCT8, COPE, COPZ1, COX5A, FIBP, GPX4, LAMTOR4, MDH1, NDUFC2, NDUFS7, PSMB2, PSMB6, TCEA1, TKT
Most correlated modules
- Glycolysis & OxPhos · correlation 0.97
- Actin Cytoskeleton Dynamics · correlation 0.97
- Proteasome & TCA · correlation 0.96
- Mitochondrial OxPhos Biogenesis · correlation 0.96
- Mitochondrial Lysosomal Housekeeping · correlation 0.96
- ILC1 Cytoskeletal Metabolic · correlation 0.96
- Mitochondrial OxPhos · correlation 0.96
- Mitochondrial OxPhos · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.