Actin Cytoskeleton Remodeling
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 26 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 26 genes have a known function matching the annotation |
Why this annotation
The module contains a strong actin cytoskeleton remodeling signature: CFL1 (cofilin-1, actin depolymerization), MYL6 and MYL12B (myosin light chains, actomyosin contractility), ARPC2 and ARPC3 (Arp2/3 complex subunits, branched actin nucleation), TMSB4X (thymosin beta-4, G-actin sequestration). These are core/strong members. Additional genes include mitochondrial components (ATP5F1E, COX6C, NDUFB2, CHCHD2) and SRP14 (signal recognition particle). The actin/myosin program is the most coherent and distinctive feature, relevant to NK cell motility and cytotoxic synapse formation. Significantly upregulated with inflammation (delta=0.396, sig.).
Genes
APRT, ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2, COX6C, COX8A, ELOB, HMGN1, MYL12B, MYL6, NDUFB2, NDUFS5, OAZ1, OST4, POLR2L, SEC61G, SERF2, SRP14, TMA7, TMSB4X, UBL5, UQCRQ
Most correlated modules
- Proteasome ER Proteostasis · correlation 0.95
- Mitochondrial OxPhos · correlation 0.95
- RNA Splicing Processing · correlation 0.95
- SUMOylation Program · correlation 0.94
- ILC-1 identity · correlation 0.94
- Mitochondrial Translation · correlation 0.93
- Protein Biogenesis & Import · correlation 0.93
- RNA Processing & Proteostasis · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.