Mixed Proteostasis Metabolism
Gene co-expression module in Innate lymphoid cells
| Category | Metabolism |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 13 of 27 genes have a known function matching the annotation |
Why this annotation
The module has moderate coherence and a mixed gene composition. MRPL36 and MRPL52 are mitochondrial ribosomal proteins. PSMB5 is a proteasome beta subunit. ADRM1 is a proteasome regulatory subunit (19S). NDUFB4, NDUFA6, UQCRFS1, COX17 are mitochondrial ETC subunits. PDIA3 is an ER protein disulfide isomerase. TMED9 is a COPI/ER-Golgi trafficking protein. ATP6V0B is a V-ATPase subunit. SLC16A3 is a monocarboxylate transporter (lactate). EIF3I is a translation initiation factor. ILF2 is an RNA-binding protein. LAMTOR5 is a lysosomal mTOR scaffold. HPRT1 is a purine salvage enzyme. DNAJC8 is a DnaJ chaperone. ISOC1 is an isochorismatase-domain protein. RHOF is a Rho GTPase. ANXA11 is an annexin. The module is mixed: mitochondrial, proteasomal, ER, and translation components. The moderate coherence reflects this heterogeneity. The dominant theme across the batch neighborhood is ILC1 housekeeping metabolism; this module represents a mixed metabolic/proteostasis program.
Genes
ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I, HPRT1, ILF2, ISOC1, LAMTOR5, MEAF6, MRPL36, MRPL52, NDUFA6, NDUFB4, ORMDL2, P4HB, PDIA3, PSMB5, RHOF, SLC16A3, TMED9, UBA2, UQCRFS1, VAPA
Most correlated modules
- Mitochondrial Lysosomal Housekeeping · correlation 0.96
- Mitochondrial OxPhos · correlation 0.95
- Mitochondrial OxPhos Biogenesis · correlation 0.95
- Glycolysis & OxPhos · correlation 0.95
- Actin Cytoskeleton Dynamics · correlation 0.94
- Glycolysis & OxPhos · correlation 0.94
- Proteasome & TCA · correlation 0.94
- ILC1 Cytoskeletal Metabolic · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.