Glycolysis & OxPhos
Gene co-expression module in Innate lymphoid cells
| Category | Metabolism |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
GAPDH and ENO1 are key glycolytic enzymes. UQCR11 and UQCR10 are subunits of mitochondrial complex III (ubiquinol-cytochrome c reductase). ATP6V1F is a V-ATPase subunit involved in lysosomal/vacuolar acidification. ARPC4 is an Arp2/3 complex subunit (actin branching). FKBP1A is an immunophilin/chaperone. BRK1 is a WAVE complex component (actin polymerization). PYURF is a mitochondrial protein involved in complex I assembly. SELENOF is an ER-resident selenoprotein. NEDD8 is a ubiquitin-like modifier. The module mixes glycolysis (GAPDH, ENO1), mitochondrial ETC (UQCR10, UQCR11, PYURF), and actin dynamics (ARPC4, BRK1). Given the neighbor context (M24 = actin, M63/M96 = OxPhos), this module bridges glycolysis and mitochondrial respiration — consistent with metabolic reprogramming in ILC1s. The dominant signal is glycolytic/metabolic.
Genes
ARPC4, ATP6V1F, BRK1, ENO1, FKBP1A, GAPDH, NEDD8, PYURF, SELENOF, UQCR10, UQCR11
Most correlated modules
- Proteasome & COPI Trafficking · correlation 0.97
- Actin Cytoskeleton Dynamics · correlation 0.97
- Mitochondrial OxPhos Biogenesis · correlation 0.96
- Mitochondrial Lysosomal Housekeeping · correlation 0.96
- Mitochondrial OxPhos · correlation 0.96
- Lipid & Isoprenoid Metabolism · correlation 0.96
- Mitochondrial OxPhos · correlation 0.95
- ILC-1 identity · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.