KLRK1 — Killer cell lectin like receptor K1
KLRK1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLRK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | NKG2D Cytotoxic Activation cytotoxicity | CCND3, GABARAP, HCST, HDAC10, IER3IP1, IL2RG, KRTCAP2, LAMTOR4 +11 more | |
| Innate lymphoid cells | NK Activating Receptors Cytotoxicity | CAT, CRACDL, ELAPOR1, FLT3LG, KRTCAP2, LTA4H, MFSD10, MLLT3 +7 more | View in SCUBA |
| Natural Killer cells | Interferon NK Activation Inflammation | CYRIB, IFITM1, NHERF1, PLAAT4, RNASEK, SEPTIN9, TLE5, UBE2V1 | View in SCUBA |
About the gene
| Synonyms | CD314, D12S2489E, KLR, NKG2-D, NKG2D |
|---|---|
| Chromosome | 12: 10372353-10391874 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Differentiation, Immunity, Innate immunity |
Function
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell- mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.